J.M. Ospel, G. Gascou, V. Costalat, L. Piergallini, K.A. Blackham and D.W. Zumofen.
[…]The Sim&Size software simulates case-specific intraluminal Pipeline Embolization Device behavior, wall apposition, and device length in real-time on the basis of rotational angiography DICOM data. The purpose of this multicenter study was to evaluate whether preimplantation device simulation with the Sim&Size software results in selection of different device dimensions than manual sizing.[…]
Julien Sigüenza (1,3), Desiree Pott (2), Simon Mendez (1), Simon J. Sonntag (2), Tim A.S. Kaufmann (2), Ulrich Steinseifer (2), Franck Nicoud (1).
(1) IMAG, Univ Montpellier, CNRS, Montpellier, France. (2) Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute, RWTH Aachen University, Aachen, Germany. (3) Sim&Cure, Cap Gamma, 1682 rue de la Valsière, 34790, Grabels, France.
[…]The complex fluid-structure interaction problem associated with the flow of blood through a heart valve with flexible leaflets is investigated both experimentally and numerically. In the experimental test rig, a pulse duplicator generates a pulsatile flow through a biomimetic rigid aortic root where a model of aortic valve with polymer flexible leaflets is implanted[…]
Markus Holtmannspötter (1), Mario Martinez-Galdamez (2),Matti Isokangas (4), Riccardo Ferrara (3), Mathieu Sanchez (3)
(1). Rigshospitalet Copenhagen (Denmark); (2) Fundacion Jimenez Diaz Madrid (Spain); (3) Sim&Cure (France); Oulu, Finland.
[…]Numerical simulation was previously restricted to research field and poorly applicable in clinical routine. As implants becoming more and more complex the sizing of the implant is the first crucial important step, followed by delivery and implantation of the device, to finally achieve an efficient and safe treatment. Recently Sim&Cure developed a new simulation software: Sim&Size, dedicated to implant sizing and to allow the interventionalist to perform reliable pre-therapeutic planning in real time in the angiosuite during the treatment procedure. This software opens a new window to interventional neuroradiology. In this report, we will report our clinical experience on 10 patient cases of pre-operative simulation (Fig.1 and Fig.2) for Intrasaccular device (WEB) and Flow Diverter (Pipeline). The goal is to describe the impact of this new method on the treatment strategy[…]
Gregory Gascou, Riccardo Ferrara, Dominique Ambard, Mathieu Sanchez, Kyriakos Lobotesis, Franck Jourdan, Vincent Costalat.
[…]Background and purpose Pore density (PD), surface metal coverage (SMC) and the number of wires are all different parameters which can influence the efficacy of a flow disruptor/diverter. Nevertheless, the relative importance of a parameter to induce intra-aneurysmal blood stasis is still poorly evaluated. Therefore, comparison between devices based on a unique value is not reliable. The aim of this study was to propose a new bench top parameter (the pressure reduction coefficient (PRC; ξ)) in order to assess the global haemodynamic effect of each flow diverter/disruptor to slow flow.[…]
Ferrara R.(1,2), Ambard D. (2), Sanchez M.(3), Mendez S.(1), Siguenza J.(1), Nicoud F.(1), Costalat V.(3), Jourdan F.(2)
(1) Montpellier Institute of Mathematics and Modelling (i3m) – University of Montpellier – France. (2) Mechanical and Civil Engineering Laboratory (LMGC) – University of Montpellier – France. (3) University Medical Centre of Montpellier (CHU) – France
Gregory Gascou, Riccardo Ferrara, Omer Eker, Carlos Riquelme, Alain Bonafe, Vincent Costalat.
Journal of Neuroradiology, Volume 43, Issue 2, Pages 110-111
O. Eker, K. Zouaoui Boudjeltia, R. A. Corredor Jerez, E. Lebars, M. Sanchez, A. Bonafé, V. Costalat, and G. Courbebaisse.
J Cereb Blood Flow Metab. 2015 Dec;35(12):2070-9. doi: 10.1038/jcbfm.2015.176.
[…]Little is known about the hemodynamic disturbances induced by the cerebral aneurysms in the parent artery and the effect of flow diverter stents (FDS) on these latter. A better understanding of the aneurysm-parent vessel complex relationship may aid our understanding of this disease and to optimize its treatment.[…]
Dominique Ambard, Omer Eker, Simon Le Floc’h, Vincent Costalat, Mathieu Sanchez, et al.
21st congress of the european society of biomechanics, Jul 2015, Prague, Czech Republic. 21st congress of the european society of biomechanics.
[…]The prevalence of unruptured intracranial aneurysms in the general population, as reported by a recent review [Wardlaw, 2000], ranges between 3% and 6.6%. However, the incidence of ruptured aneurysms is low, with approximately 0.5% per year, suggesting that very few aneurysms rupture. Clearly, new patient-specific indexes predicting aneurysm risk of rupture should be proposed, in order to guide therapeutic decision for unruptured aneurysm[…]
Sanchez M., Ecker O., Ambard D., Jourdan F., Nicoud F., Mendez S. et al.
AJNR Am. J. Neuroradiol. 2014 35: 1765-1771.
[…]The present study follows an experimental work based on the characterization of the biomechanical behavior of the aneurysmal wall and a numerical study where a significant difference in term of volume variation between ruptured and unruptured aneurysm was observed in a specific case.[…]
Franck Jourdan, Mathieu Sanchez, Dominique Ambard, Simon Mendez, Franck Nicoud, et al.
7th World Congress of Biomechanics, Jul 2014, Boston, United States.
[…]Between 2 and 6 % of the population harbour at least one intracranial aneurysm and around 0.5% ofthem are expected to rupture. Given the human and economic cost associated with cerebral vasculardiseases, a systematic medical screening of intracranial aneurysms would be worth organizing. However,the per-procedural risk being about 1%, no such screening is organized because a reliable assessment ofthe aneurysms vulnerability is still[…]
M. Sanchez, D. Ambard, V. Costalat, S. Mendez, F. Jourdan, F. Nicoud.
Annals of Biomedical Engineering. January 2013, Volume 41, Issue 1, pp 28-40
[…]This study is a step towards a new biomechanical-based measurement of the patient specific risk of rupture of cerebral aneurysms. Following a previous experimental investigation suggesting a correlation between the risk of rupture and the material properties of cerebral aneurysms, fluid-structure interaction simulations are performed to compare the deformations of a patient-specific aneurysm when using degraded or undegraded materials. Results show that material properties have a major impact on the magnitude of systolic/diastolic aneurysmal volume variations along the cardiac cycle.[…]
Mathieu Sanchez, Dominique Ambard, Costalat Vincent, Franck Jourdan, Franck Nicoud.
10e colloque national en calcul des structures, May 2011, Giens, France.
[…]L’objectif de cette étude est de proposer une mesure du risque de rupture d’anévrysmes cérébraux associé à la pathologie d’un patient donné. Dans ce cadre, une chaîne numérique de traitement des images morphologiques, des données hémodynamiques et rhéologiques, est mise en œuvre afin d’avoir accès aux données biomécaniques inaccessibles directement par l’imagerie médicale. Nous accédons aux contraintes et déformations dans la paroi en adoptant les propriétés des matériaux déterminées par nos investigations expérimentales, puis en utilisant un modèle numérique de couplage fluide/structure[…]
Costalat V(1), Sanchez M, Ambard D, Thines L, Lonjon N, Nicoud F, Brunel H, Lejeune JP et al.
J Biomech. 2011 Oct 13;44(15):2685-91.
doi: 10.1016/j.jbiomech.2011.07.026. Epub 2011 Sep 14.
[…]Individual rupture risk assessment of intracranial aneurysms is a major issue in the clinical management of asymptomatic aneurysms. Aneurysm rupture occurs when wall tension exceeds the strength limit of the wall tissue. At present, aneurysmal wall mechanics are poorly understood and thus, risk assessment involving mechanical properties is inexistent[…]